microbiota, is well known to be crucial for the health maintenance of the host.
The composition and functionality of complex and rich community of microbes living on the surfaces and cavities of the mammal’s body, i.e. These data confirm the importance of the gut microbial ecosystem as an adaptive partner for the mammalian biology and health, independently of the host phylogeny.
In addition, we found an enrichment of short-chain fatty acids and carbohydrate degradation products in naked mole-rat compared to human samples. Interestingly, some compositional gut microbiota peculiarities were also shared with human gut microbial ecosystems of centenarians and Hadza hunter-gatherers, considered as models of a healthy gut microbiome and of a homeostatic and highly adaptive gut microbiota-host relationship, respectively. Here we characterize for the first time the intestinal microbial ecosystem of the naked mole-rat in comparison to humans and other mammals, highlighting peculiarities related to the specific living environment, such as the enrichment in bacteria able to utilize soil sulfate as a terminal electron acceptor to sustain an anaerobic oxidative metabolism. These features make this wild rodent an excellent model to study the biology of healthy aging and longevity. Shown with optional activity sensors.The naked mole-rat ( Heterocephalus glaber) is a subterranean mouse-sized African mammal that shows astonishingly few age-related degenerative changes and seems to not be affected by cancer.
It does not account for spillage or foraging.ĭouble Feeder Cages: The Double Feeder Cage supports two feeders with food intake monitoring for diet preference experiments. Over Head Feeder Cages: The Over Head Feeder is an adaptation of our popular center feeder that places the food in a location more familiar to the subjects. The End Feeder provides more floor space for active subjects. Not compatible with Y axis activity monitoring.Ĭorner Feeder Cages: The Corner Feeder Cage maintains the same sealed environment but adds an external feeder to the corner of the cage to allow food intake measurements and placement of a Y axis activity sensor. An adjustable food guard allows mechanical fine tuning of food access to minimize foraging.Įnd Feeder Cages: The End Feeder Cage maintains the same sealed environment but adds an external feeder to the side of the cage to allow food intake measurements. The Center Feeder is the most popular and universal in application, supporting all subject body types from lean to obese. Standard Cages: The basic animal cage providing a sealed environment suitable for measuring Oxygen consumption and Carbon Dioxide production.Ĭenter Feeder Cages: The Center Feeder Cage maintains the same sealed environment but adds a feeder to the center of the cage to allow food intake measurements. Food and water may be replenished during experiment execution without the need for system restart. Oxymax/CLAMS provides fully automated operation for experiments lasting up to three days. All data can be reviewed graphically & numerically in real-time during collection. Additional data reduction tools allow for the de-collating of data by parameter to facilitate analysis from a parameter perspective. The resulting secure data sets can be exported to Comma Separated Value (CSV) files and provide the link between Oxymax/CLAMS and your existing data analysis tools. Operation of Oxymax/CLAMS and data collection is performed by an integrated program. Any system can be expanded by way of more chambers and/or features at any time. Oxymax/CLAMS is constructed on a semi-custom basis incorporating parameters and features specific to your research. Incorporating sub-systems for open circuit calorimetry, activity, body mass, feeding, drinking, food access control, running wheel, urine collection, sleep detection, body core temperature and heart rate in an optional environmental chamber: Oxymax/CLAMS is the one-test solution for simultaneous multi parameter assessment of 1 to 32 test animals. Contact us for more details.Ĭolumbus Instruments Comprehensive Lab Animal Monitoring System CLAMS is the premiere system of its kind. Some triggers include low O2, high CO2, air flow issues, an absence of drinking behavior, etc.
#Brigitte siberian mouse software
New software alarm option! The latest version of the Oxymax software can send an email or sms alert according to certain conditions.
0 kommentar(er)
